Research & Innovation

Featured Publications

Hepatocyte Gene Transplantation for Crigler–Najjar Syndrome II

Sage Publications, 2005

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Image-guided robotic stereotactic radiosurgery for unresectable liver metastases

Anticancer research, 2009

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Hepatocyte transplantation in the treatment of acute liver failure

Sage Publications, 2003

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Core Research Themes

Bio‑artificial Liver — ALEX™ Platform

Inventor & patent holder of the ALEX bio‑artificial liver (PCT US97/22727), featuring an autologous biomatrix that extends hepatocyte viability for extracorporeal support.

Hepatocyte & Gene Transplantation

Pioneered the world’s first cell‑based gene graft curing Crigler–Najjar syndrome through minimally invasive hepatocyte infusion.

Robotic Stereotactic Radiosurgery

Developed fiducial‑guided Synchrony® tracking, enabling CyberKnife treatment of moving extra‑cranial tumours.

Quality‑of‑Life Metrics (PEQUOL)

Created and validated the PEQUOL questionnaire, a prognostic tool for mental and relational well‑being in transplant patients.

Key Collaborations

Harvard Medical School

UPMC Pittsburgh

DRI Miami

Stanford

UCLA

Loyola University Chicago

Groote Schuur Hospital

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